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Ribosome Biogenesis and Function in Cancer: From Mechanisms to Therapy

31 Jul 2025

Abstract excerpt

Ribosome biogenesis is a highly coordinated, multi-step process that assembles the ribosomal machinery responsible for translating mRNAs into proteins. It begins with the rate-limiting step of RNA polymerase I (Pol I) transcription of the 47S ribosomal RNA (rRNA) genes within a specialised nucleolar region in the nucleus, followed by rRNA processing, modification, and assembly with ribosomal proteins and the 5S...

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PMID: 40805230
DOI: 10.3390/cancers17152534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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