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Article

FUS contributes to mTOR-dependent inhibition of translation.

The Journal of biological chemistry - 25 Dec 2020

Sévigny Myriam, Bourdeau Julien Isabelle, Venkatasubramani Janani Priya, Hui Jeremy B, Dutchak Paul A, Sephton Chantelle F

Abstract excerpt

The amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)-linked RNA-binding protein called FUS (fused in sarcoma) has been implicated in several aspects of RNA regulation, including mRNA translation. The mechanism by which FUS affects the translation of polyribosomes has not been established. Here we show that FUS can associate with stalled polyribosomes and that this association is sensitive to...

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Identifiers

PMID: 33082139
DOI: 10.1074/jbc.RA120.013801
PMCID: PMC7939483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FUS contributes to mTOR-dependent inhibition of translation.PMID 33082139Read ↗

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FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTDSemantic proximity Read ↗

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