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Article

Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAs

16 Feb 2024

Abstract excerpt

A central mechanism of mTOR complex 1 (mTORC1) signaling is the coordinated translation of ribosomal protein and translation factor mRNAs mediated by the 5'-terminal oligopyrimidine motif (5'TOP). Recently, La-related protein 1 (LARP1) was proposed to be the specific regulator of 5'TOP mRNA translation downstream of mTORC1, while eIF4E-binding proteins (4EBP1/2) were suggested to have a general role in...

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PMID: 38363833
DOI: 10.1126/sciadv.adi7830

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Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAsPMID 38363833Read ↗

Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAsSemantic proximity Read ↗

The LARP1 RRM functions as a ribosome responsive regulator of TOP mRNAsSemantic proximity Read ↗

Genes with 5′ terminal oligopyrimidine tracts preferentially escape global suppression of translation by the SARS-CoV-2 Nsp1 proteinSemantic proximity Read ↗

mRNA 5′ terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decaySemantic proximity Read ↗

Genes with 5′ terminal oligopyrimidine tracts preferentially escape global suppression of translation by the SARS-CoV-2 Nsp1 proteinSemantic proximity Read ↗

Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in protein translationSemantic proximity Read ↗

Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6kSemantic proximity Read ↗

5’ UTR recruitment of eIF4GI or DAP5 drives cap-independent translation for a subset of human mRNAsSemantic proximity Read ↗

Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiationSemantic proximity Read ↗

NaP-TRAP, a novel massively parallel reporter assay to quantify translation controlSemantic proximity Read ↗

Poly(A) binding protein abundance regulates eukaryotic translation initiation factor 4F assembly in human cytomegalovirus-infected cellsSemantic proximity Read ↗

Unbiased screen of human transcriptome reveals an unexpected role of 3′UTRs in translation initiationSemantic proximity Read ↗

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