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Article

Post-Translational Regulation of ARF: Perspective in Cancer

4 Aug 2020

Abstract excerpt

Tumorigenesis can be induced by various stresses that cause aberrant DNA mutations and unhindered cell proliferation. Under such conditions, normal cells autonomously induce defense mechanisms, thereby stimulating tumor suppressor activation. ARF, encoded by the CDKN2a locus, is one of the most frequently mutated or deleted tumor suppressors in human cancer. The safeguard roles of ARF in tumorigenesis are mainly...

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PMID: 32759846
DOI: 10.3390/biom10081143

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