Article

Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAs

2023-05-22

Abstract excerpt

A central mechanism of mTOR complex 1 (mTORC1) signaling is the coordinated translation of ribosomal protein and translation factor mRNAs mediated by the 5′-terminal oligopyrimidine motif (5′TOP). Recently, La-related protein 1 (LARP1) has been proposed to be the specific regulator of 5′TOP mRNA translation downstream of mTORC1, while eIF4E-binding proteins (4EBP1/2) were suggested to have a general role in repres...

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Literature Corpus work: dddaf399-0171-5159-94ef-21f4c263ed61
DOI: 10.1101/2023.05.22.541712

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Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAsDOI 10.1101/2023.05.22.541712Read

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