Article
Capturing Differential Allele-Level Expression and Genotypes of All Classical HLA Loci and Haplotypes by a New Capture RNA-Seq Method.
Frontiers in immunology - 1 Jan 2020
Yamamoto Fumiko, Suzuki Shingo, Mizutani Akiko, Shigenari Atsuko, Ito Sayaka, Kametani Yoshie, Kato Shunichi, Fernandez-Viña Marcelo, Murata Makoto, Morishima Satoko, Morishima Yasuo, Tanaka Masafumi, Kulski Jerzy K, Bahram Seiamak, Shiina Takashi
Abstract excerpt
The highly polymorphic human major histocompatibility complex (MHC) also known as the human leukocyte antigen (HLA) encodes class I and II genes that are the cornerstone of the adaptive immune system. Their unique diversity (>25,000 alleles) might affect the outcome of any transplant, infection, and susceptibility to autoimmune diseases. The recent rapid development of new next-generation sequencing (NGS) methods...
Topics
- Gene Frequency
- Genetic Loci
- HLA Antigens
- Haplotypes
- High-Throughput Nucleotide Sequencing
- Humans
- Polymorphism, Single Nucleotide
- Predictive Value of Tests
- RNA-Seq