Article

Extraordinary diversity of HLA class I gene expression in single cells contribute to the plasticity and adaptability of human immune system

2019-08-05

Abstract excerpt

HLA, the coding genes of human major histocompatibility (MHC) proteins, play a crucial role in the human adaptive immune system by presenting antigenic peptides to T cell receptors on T cells. HLA-A, HLA-B and HLA-C, these 3 Class I HLA genes are one of the most polymorphic loci in the human genome. For decades, HLA typing has been performed prior to tissue and stem cell transplantation. However, beyond the role i...

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Literature Corpus work: b2bf9d54-6051-54ce-8518-e3dd2a1d138d
DOI: 10.1101/725119

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