Article

A comprehensive workflow for allele-specific immune gene quantification and expression analysis in single-cell RNA-seq data

2024-12-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Motivation</h4> Immune molecules such as B and T cell receptors, human leukocyte antigens (HLAs), or killer Ig-like receptors (KIRs) are encoded in the most genetically diverse loci of the human genome. Many of these immune genes exhibit remarkable allelic diversity across populations. While computational methods for HLA typing from bulk RNA sequencing data have emerged, streamlined solutio...

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Literature Corpus work: 17a73168-8614-52bd-ab1e-a48a57222963
DOI: 10.1101/2024.12.10.627679

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