Article

A role for YY1 in sex-biased transcription revealed through X-linked promoter activity and allelic binding analyses

2016-03-21

Abstract excerpt

Sex differences in susceptibility and progression have been reported in numerous diseases. Female cells have two copies of the X chromosome with X-chromosome inactivation imparting mono-allelic gene silencing for dosage compensation. However, a subset of genes, named escapees, escape silencing and are transcribed bi-allelically resulting in sexual dimorphism. Here we conducted analyses of the sexes using human dat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cf7167cf-88fc-5174-bd18-1e5eced796c2
DOI: 10.1101/044172

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A role for YY1 in sex-biased transcription revealed through X-linked promoter activity and allelic binding analysesDOI 10.1101/044172Read

YY1 binding association with sex-biased transcription revealed through X-linked transcript levels and allelic binding analyses.Semantic proximity Read

Escape from X inactivation varies across genes and tissues and shapes sex-biased sex chromosome gene expressionSemantic proximity Read

Inferring genes that escape X-Chromosome inactivation reveals important contribution of variable escape genes to sex-biased diseases.Semantic proximity Read

X-factors in human disease: impact of gene content and dosage regulation.Semantic proximity Read

Human Genes Escaping X-inactivation Revealed by Single Cell Expression DataSemantic proximity Read

Single Cell Expression Data Reveal Human Genes that Escape X-Chromosome InactivationSemantic proximity Read

Escape from X-inactivation in twins exhibits intra- and inter-individual variability across tissues and is heritable.Semantic proximity Read

geneXplore: An Interactive Browser for X Chromosome-Wide Association Study ResultsSemantic proximity Read

Extensive cellular heterogeneity of X inactivation revealed by single-cell allele-specific expression in human fibroblastsSemantic proximity Read

YY1 binding is a gene-intrinsic barrier to Xist-mediated gene silencing.Semantic proximity Read

The human Y and inactive X chromosomes similarly modulate autosomal gene expressionSemantic proximity Read

The human inactive X chromosome modulates expression of the active X chromosomeSemantic proximity Read