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Spatial multi-omics analysis reveals vimentin <sup>high</sup> macrophages–endothelial cells niche shapes CAFs heterogeneity in colorectal cancer metastasis

2026-08-27

Abstract excerpt

The spatial architecture of the tumor microenvironment (TME) is pivotal in the progression of colorectal cancer (CRC) liver metastasis. By applying high-plex spatial multi-omic mapping and neighborhood analysis to a discovery cohort of colorectal cancer primary tumor (PT) and paired liver metastases (LM), we identified a specialized vimentin high macrophages-endothelial cells niche that orchestrates cancer-associ...

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Literature Corpus work
cf6d085e-20c9-5b76-b2ec-72b10c9966f2
DOI
10.64898/2026.08.26.747355
Open publication

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Spatial multi-omics analysis reveals vimentin <sup>high</sup> macrophages–endothelial cells niche shapes CAFs heterogeneity in colorectal cancer metastasisDOI 10.64898/2026.08.26.747355
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