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Article

Spatial Heterogeneity, Stromal Phenotypes, and Therapeutic Vulnerabilities in Colorectal Cancer Peritoneal Metastasis

29 Apr 2025

Abstract excerpt

PURPOSE: Peritoneal metastases (PM) in colorectal cancer portend a poor prognosis. We sought to elucidate molecular features differentiating primary tumors (PT) from PMs and actionable targets facilitating transcoelomic dissemination and progression. EXPERIMENTAL DESIGN: We performed multiomic profiling of 227 samples from 136 patients, including 56 PTs and 120 synchronous PMs comprising 34 matched PT-PM pairs....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40299767
DOI: 10.1158/1078-0432.ccr-24-3780

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