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High-definition spatial transcriptomic profiling of immune cell populations in colorectal cancer

1 Jun 2025

Abstract excerpt

A comprehensive understanding of cellular behavior and response to the tumor microenvironment (TME) in colorectal cancer (CRC) remains elusive. Here, we introduce the high-definition Visium spatial transcriptomic technology (Visium HD) and investigate formalin-fixed paraffin-embedded human CRC samples (n = 5). We demonstrate the high sensitivity, single-cell-scale resolution and spatial accuracy of Visium HD,...

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PMID: 40473992
DOI: 10.1038/s41588-025-02193-3

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