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Spatial transcriptomics atlas reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment components in colorectal cancer

6 Jul 2022

Abstract excerpt

BACKGROUND: The tumor-promoting role of tumor microenvironment (TME) in colorectal cancer has been widely investigated in cancer biology. Cancer-associated fibroblasts (CAFs), as the main stromal component in TME, play an important role in promoting tumor progression and metastasis. Hence, we explored the crosstalk between CAFs and microenvironment in the pathogenesis of colorectal cancer in order to provide...

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Ferroptosis and cancer prognosis
Immune cells in cancer
Single-cell and spatial transcriptomics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35794563
DOI: 10.1186/s12967-022-03510-8

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