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Pan-Cancer Spatial Profiling Reveals Conserved Subtypes and Niches of Cancer-Associated Fibroblasts

29 May 2025

Abstract excerpt

Solid cancers are complex "ecosystems" comprised of diverse cell types and extracellular molecules, in which heterotypic interactions significantly influence disease etiology and therapeutic response. However, our current understanding of tumor microenvironments remains incomplete, hindering the development and implementation of novel tumor microenvironment-targeted drugs. To maximize cancer therapeutic...

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PMID: 40440095
DOI: 10.1158/0008-5472.can-25-2181

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