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Deep immunophenotyping reveals clinically distinct cellular states and ecosystems in large-scale colorectal cancer

27 Jul 2023

Abstract excerpt

Determining the diverse cell types in the tumor microenvironment (TME) and their organization into cellular communities, is critical for understanding the biological heterogeneity and therapy of cancer. Here, we deeply immunophenotype the colorectal cancer (CRC) by integrative analysis of large-scale bulk and single cell transcriptome of 2350 patients and 53,137 cells. A rich landscape of 42 cellular states and 7...

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PMID: 37500893
DOI: 10.1038/s42003-023-05117-1

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