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Article

Enrichment of Cancer-Associated Fibroblasts, Macrophages, and Up-Regulated TNF-α Signaling in the Tumor Microenvironment of CMS4 Colorectal Peritoneal Metastasis.

Cancer medicine - 1 Jan 2025

Høye Eirik, Kanduri Chakravarthi, Torgunrud Annette, Lorenz Susanne, Edwin Bjørn, Larsen Stein G, Fretland Åsmund A, Dagenborg Vegar J, Flatmark Kjersti, Lund-Andersen Christin

Abstract excerpt

BACKGROUND: Metastatic colorectal cancer (mCRC) is the main cause of CRC mortality, with limited treatment options. Although immunotherapy has benefited some cancer patients, mCRC typically lacks the molecular features that respond to this treatment. However, recent studies indicate that the immune microenvironment of mCRC may be modified to enhance the effect of immune checkpoint inhibitors. This study aimed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins p21(ras)

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Source

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Identifiers

PMID: 39739693
DOI: 10.1002/cam4.70521
PMCID: PMC11683539

Genes

TNF
BRAF
CD4
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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