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Article

The landscape of cancer-associated fibroblasts in colorectal cancer liver metastases

1 Jan 2022

Abstract excerpt

Rationale: Patients with colorectal cancer die mainly due to liver metastases (CRC-LM). Although the tumor microenvironment (TME) plays an important role in tumor development and therapeutic response, our understanding of the individual TME components, especially cancer-associated fibroblasts (CAFs), remains limited. Methods: We analyzed CRC-LM CAFs and cancer cells by single-cell transcriptomics and used...

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PMID: 36438498
DOI: 10.7150/thno.72853

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