Article

Single-cell and spatial transcriptomics define a C3-centred multicellular ecology in colorectal liver metastasis

2026-08-03

Abstract excerpt

<title>Abstract</title> <p> Colorectal liver metastasis (CRLM) is shaped by malignant-cell plasticity and microenvironmental remodeling, but how malignant, stromal, vascular and myeloid states assemble spatially remains unclear. We sought to define recurrent multicellular programs associated with CRLM. We integrated a 136,995-cell single-cell atlas with copy-number inference, consensus non-negative matrix factor...

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Literature Corpus work: 8c9bb26e-330a-576b-b314-5930b4085338
DOI: 10.21203/rs.3.rs-10434952/v1

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