Article

Quantitative proteomic analysis reveals apoE4-dependent phosphorylation of the actin-regulating protein VASP

2022-06-07

Abstract excerpt

Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer’s Disease (AD). While neurons generally produce a minority of the apoE in the central nervous system, neuronal expression of apoE increases dramatically in response to stress and is sufficient to drive pathology. Currently, the molecular mechanisms of how apoE4 expression may regulate pathology are not fully understood. Here we expand upon our...

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Literature Corpus work: cf55506f-fa1f-50df-9949-0fa1109d8c7c
DOI: 10.1101/2022.06.06.495052

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