Article
APOE4 Regulates Synaptic Function by Directly Modulating the SNARE Complex Assembly
2021-04-09
Abstract excerpt
<title>Abstract</title> <p><bold>Background:</bold> The ε4 allele of the Apolipoprotein E (<italic>APOE</italic>) gene is a major genetic risk determinant of sporadic Alzheimer's disease (AD). Its protein product APOE4 has been demonstrated to coffers deleterious effects for various neurodegenerative disorders related to cognitive impairment, including AD. A line of evidence implied that APOE4 affects these disea...
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Identifiers and source
- Literature Corpus work
- c77c50b6-9388-54ef-838a-2a6f4b1e8d10
- DOI
- 10.21203/rs.3.rs-380304/v1