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Article

The influence of APOEε4 on the pTau interactome in sporadic Alzheimer's disease.

Acta neuropathologica - 21 May 2024

Thierry Manon, Ponce Jackeline, Martà-Ariza Mitchell, Askenazi Manor, Faustin Arline, Leitner Dominique, Pires Geoffrey, Kanshin Evgeny, Drummond Eleanor, Ueberheide Beatrix, Wisniewski Thomas

Abstract excerpt

APOEε4 is the major genetic risk factor for sporadic Alzheimer's disease (AD). Although APOEε4 is known to promote Aβ pathology, recent data also support an effect of APOE polymorphism on phosphorylated Tau (pTau) pathology. To elucidate these potential effects, the pTau interactome was analyzed across APOE genotypes in the frontal cortex of 10 advanced AD cases (n = 5 APOEε3/ε3 and n = 5 APOEε4/ε4), using a...

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Identifiers

PMID: 38772917
DOI: 10.1007/s00401-024-02744-8
PMCID: PMC11108952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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