Article

Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism

2025-07-04

Abstract excerpt

<h4>Summary</h4> Metabolic flexibility, the capacity to adapt fuel utilization in response to nutrient availability, is essential for maintaining energy homeostasis and preventing metabolic disease. Here, we investigate the role of Ulk1 phosphorylation at serine 555 (S555), a site regulated by AMPK, in coordinating metabolic switching following short-term caloric restriction and fasting. Using Ulk1(S555A) global...

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Literature Corpus work: cf50a167-e916-58d8-8f06-dba8310bf468
DOI: 10.1101/2025.06.30.662412

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