Article
ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy.
Molecular cell - 5 May 2016
Li Terytty Yang, Sun Yu, Liang Yu, Liu Qing, Shi Yuzhe, Zhang Chen-Song, Zhang Cixiong, Song Lintao, Zhang Pu, Zhang Xianzhong, Li Xiaotong, Chen Tao, Huang Hui-Ying, He Xiadi, Wang Yi, Wu Yu-Qing, Chen Shaoxuan, Jiang Ming, Chen Canhe, Xie Changchuan, Yang James Y, Lin Yan, Zhao Shimin, Ye Zhiyun, Lin Shu-Yong, Chiu Daniel Tsun-Yee, Lin Sheng-Cai
Abstract excerpt
Metabolic reprogramming is fundamental to biological homeostasis, enabling cells to adjust metabolic routes after sensing altered availability of fuels and growth factors. ULK1 and ULK2 represent key integrators that relay metabolic stress signals to the autophagy machinery. Here, we demonstrate that, during deprivation of amino acid and growth factors, ULK1/2 directly phosphorylate key glycolytic enzymes...
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