Article

Systematic Analysis of Human Tissue- and Cell-Specific Metabolic Models Identifies High-Sugar, High-Fat Diet–Induced Liver Dysregulation

2026-02-19

Abstract excerpt

Human tissues exhibit specialized metabolic functions that are essential for maintaining whole-body metabolic homeostasis. To systematically characterize organ- and cell-type-specific metabolic heterogeneity, we constructed 32 tissue-specific and 81 cell-type-specific enzyme-constrained genome-scale metabolic models (ecGEMs) by integrating the global human metabolic network with the tissue- and single-cell transcr...

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Literature Corpus work: 56e6e83c-030c-5c6b-b9ea-880b1b033fa9
DOI: 10.64898/2026.02.18.706568

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Systematic Analysis of Human Tissue- and Cell-Specific Metabolic Models Identifies High-Sugar, High-Fat Diet–Induced Liver DysregulationDOI 10.64898/2026.02.18.706568Read

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