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Whole body MondoA deletion protects against diet-induced obesity through uncontrolled multi-organ substrate utilization and futile cycling

2025-10-07

Abstract excerpt

<h4>Objective</h4> Delineating the nodal control points that maintain whole-body energy homeostasis is critical for understanding potential treatments of obesity and cardiometabolic diseases. The nutrient-sensing transcription factor MondoA is a regulator of skeletal muscle fuel storage, where muscle-specific inhibition improves glucose tolerance and insulin sensitivity. However, the role of MondoA in whole body...

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Literature Corpus work
f500a318-0ec1-51bc-99e0-1049373da0b5
DOI
10.1101/2025.10.06.680559
Open publication

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Whole body MondoA deletion protects against diet-induced obesity through uncontrolled multi-organ substrate utilization and futile cyclingDOI 10.1101/2025.10.06.680559
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