Article

Hepatic fructose metabolism is antagonized by growth hormone/insulin-like growth factor signaling via regulation of ketohexokinase expression

2025-01-02

Abstract excerpt

Overconsumption of added sugars such as fructose has been associated with a remarkable decline in metabolic health. Fructose is primarily metabolized by the small intestines and the liver, via phosphorylation mediated by ketohexokinase (KHK). KHK activity is traditionally viewed as lacking negative feedback mechanisms, such as those present to limit glucose metabolism, leading to excessive fat accumulation charact...

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Literature Corpus work: 236bff5e-3ddb-5deb-832c-b3b2695ab385
DOI: 10.1101/2025.01.01.630846

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