Article
FNIP1 variants are associated with favourable metabolism in 1 million humans.
Nature - 1 Sept 2026
Hindy George, Adam Rene C, Sosina Olukayode, Pryce Dwaine, Blair David, Herman Joseph, Lee Joseph, Dornbos Peter, Mayerhofer Ernst, Gilly Arthur, Hunt Charleen, Geraghty Benjamin, Landheer Karl, Ganel Liron, Baldassari Antoine, Zhang Chuanyi, Mintah Ivory, Sun Daphne, Coppola Angel, Brown Kyle, Nguyen Tram, Xia Xin, Rader Daniel J, Melander Olle, Still Christopher D, Berumen Jaime, Kuri-Morales Pablo, Alegre-Díaz Jesus, Torres Jason M, Emberson Jonathan R, Collins Rory, Tapia-Conyer Roberto, Balasubramanian Suganthi, Jones Marcus B, LeBlanc Michelle G, Murphy Andrew J, Kyratsous Christos A, Overton John D, Reid Jeffrey G, Abecasis Goncalo R, Marchini Jonathan, Willer Cristen, Yancopoulos George D, Sleeman Mark W, Bovijn Jonas, Locke Adam, Baras Aris, Verweij Niek, Gusarova Viktoria, Lotta Luca A
Abstract excerpt
Altered energy metabolism is a shared driver across cardiometabolic diseases-the leading cause of death globally1. Energy metabolism varies between individuals and is partly heritable2-9. Here, to investigate the genetic basis of energy metabolism, we perform an exome-sequencing analysis of 1,032,116 people from America, Europe and Asia, and estimate associations between rare protein-coding variants and the ratio...
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