Article

The genetic and dietary landscape of the muscle insulin signalling network

2023-06-22

Abstract excerpt

Metabolic disease is caused by a combination of genetic and environmental factors, yet few studies have examined how these factors influence signal transduction, a key mediator of metabolism. Using mass spectrometry-based phosphoproteomics, we quantified 23,126 phosphosites in skeletal muscle of five genetically distinct mouse strains in two dietary environments, with and without acute in vivo insulin stimulation...

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Identifiers and source

Literature Corpus work: 8472060b-34f5-5fde-b059-88a05cecb620
DOI: 10.1101/2023.06.21.546001

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