Article

The AMPK-related kinase NUAK1 regulates neuronal morphogenesis through the RNA splicing co-factor SON

2025-10-10

Abstract excerpt

<h4>ABSTRACT</h4> In recent years, alternative splicing emerged as a major mechanism controlling gene-regulatory networks during brain development, yet how alternative splicing is tuned to the dynamic alterations underlying neuronal maturation remains poorly understood. Here, we identified that NUAK1, an AMPK-related kinase linked to neurodevelopmental disorders, is a key regulator of alternative splicing in deve...

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Literature Corpus work: cf47e3c9-2a19-5e23-9f78-23b7484aa684
DOI: 10.1101/2025.10.10.681550

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