Article

Functional diversification of Ser-Arg rich protein kinases to control ubiquitin-dependent neurodevelopmental signalling

2020-04-02

Abstract excerpt

<h4>SUMMARY</h4> Conserved protein kinases with core cellular functions have been frequently redeployed during metazoan evolution to regulate specialized developmental processes. Ser-Arg Repeat Protein Kinase (SRPK) is one such conserved eukaryotic kinase, which controls mRNA splicing. Surprisingly, we show that SRPK has acquired a novel function in regulating a neurodevelopmental ubiquitin signalling pathway. In...

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Literature Corpus work: 6912c1ad-ded9-59c6-8334-51db6a6e10a4
DOI: 10.1101/2020.04.02.005041

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