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Article

Discovery of a non-canonical function of SYNGAP1 at early stages of human cortical neurogenesis.

Nature neuroscience - 1 Dec 2023

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PMID: 37996527
DOI: 10.1038/s41593-023-01486-2

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Discovery of a non-canonical function of SYNGAP1 at early stages of human cortical neurogenesis.PMID 37996527Read ↗

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The autism-associated gene SYNGAP1 regulates human cortical neurogenesisSemantic proximity Read ↗

Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis.Semantic proximity Read ↗

Species-conserved SYNGAP1 phenotypes associated with neurodevelopmental disorders.Semantic proximity Read ↗

<i>SYNGAP1</i> haploinsufficiency disrupts early neurodevelopment and accelerates intrinsic neuronal maturation in human patient-derived modelsSemantic proximity Read ↗

Disruption of the SYNGAP1 PDZ ligand motif accelerates differentiation of human iPSC-derived GABAergic neuronsSemantic proximity Read ↗

Syngap1 and the development of murine neocortical progenitor cellsSemantic proximity Read ↗

Novel de novo intronic variant of SYNGAP1 associated with the neurodevelopmental disordersSemantic proximity Read ↗

SYNGAP1-related disorder: pathophysiology, epilepsy, cognitive and behavioral phenotypes, and precision therapeutic approaches.Semantic proximity Read ↗

The human-specific paralogs SRGAP2B and SRGAP2C differentially modulate SRGAP2A-dependent synaptic developmentSemantic proximity Read ↗

Mouse models of <i>SYNGAP1</i> -related intellectual disabilitySemantic proximity Read ↗

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