Article

SAM68-regulated ALE selection of Pcdh15 maintains proper synapse development and function

2023-04-05

Abstract excerpt

Thousands of mammalian genes encode alternatively spliced isoforms in their 3’ untranslated region (3’UTR). Alternative 3’UTR diversity may contribute to several neurological processes in developing and adult brains. SAM68 is the key splicing regulator for the diversity of neuronal 3’UTR isoforms through alternative last exon (ALE) selection. However, the mechanisms underlying the control of splicing at the 3’ end...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6e1c7331-f2aa-5a71-8440-38b9551ef501
DOI: 10.1101/2023.04.04.535307

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SAM68-regulated ALE selection of Pcdh15 maintains proper synapse development and functionDOI 10.1101/2023.04.04.535307Read

Mechanisms of Neuronal Alternative Splicing and Strategies for Therapeutic InterventionsSemantic proximity Read

Transcriptome-wide alternative mRNA splicing analysis reveals post-transcriptional regulation of neuronal differentiationSemantic proximity Read

A pair of RNA-binding proteins controls networks of splicing events contributing to specialization of neural cell types.Semantic proximity Read

Identification of In Vivo, Conserved, TAF15 RNA Binding Sites Reveals the Impact of TAF15 on the Neuronal TranscriptomeSemantic proximity Read

Investigating Alzheimer's Disease-Associated Genes Using Differential Splicing Frequency AnalysisSemantic proximity Read

The role and expression of the protocadherin-alpha clusters in the CNS.Semantic proximity Read

Integrator complex subunit 15 controls mRNA splicing and is critical for eye developmentSemantic proximity Read

The AMPK-related kinase NUAK1 regulates neuronal morphogenesis through the RNA splicing co-factor SONSemantic proximity Read

Analysis of Dscam diversity in regulating axon guidance in Drosophila mushroom bodies.Semantic proximity Read

PRDM16-DT: A Brain and Astrocyte-Specific lncRNA Implicated in Alzheimer’s DiseaseSemantic proximity Read

Developmental dynamics of voltage-gated sodium channel isoform expression in the human and mouse brainSemantic proximity Read

The iStem, a long-range RNA secondary structure element required for efficient exon inclusion in the Drosophila Dscam pre-mRNA.Semantic proximity Read