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Article

Mechanisms of Neuronal Alternative Splicing and Strategies for Therapeutic Interventions

16 Oct 2019

Abstract excerpt

Many cellular and physiological processes are coordinated by regulatory networks that produce a remarkable complexity of transcript isoforms. In the mammalian nervous system, alternative pre-mRNA splicing generates functionally distinct isoforms that play key roles in normal physiology, supporting development, plasticity, complex behaviors, and cognition. Neuronal splicing programs controlled by RNA-binding...

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PMID: 31619487
DOI: 10.1523/jneurosci.1149-19.2019

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