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Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas

6 Oct 2021

Abstract excerpt

, a key component of the metabolic regulator AMP-activated protein kinase (AMPK), also showed H3K27ac enrichment in PFAs and EZHIP-WT NSCs. The AMPK activator metformin lowered EZHIP protein concentrations, increased H3K27me3, suppressed TCA cycle metabolism, and showed therapeutic efficacy in vitro and in vivo in patient-derived PFA xenografts in mice. Our data indicate that PFAs and EZHIP-WT–expressing NSCs are...

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PMID: 34613815
DOI: 10.1126/scitranslmed.abc0497

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