Article

MELK Downregulation in NPCs Disrupts Cortical Neurogenesis via G2/M Dysregulation: Autism Implications

2025-10-03

Abstract excerpt

<title>Abstract</title> <p> Maternal Embryonic Leucine Zipper Kinase (MELK) regulates cell cycle progression, but its role in neurodevelopmental disorders is unclear. We identified loss-of-function MELK variants in autism spectrum disorder (ASD) patients, suggesting MELK haploinsufficiency contributes to ASD pathogenesis. Single-cell analysis revealed preferential MELK expression in proliferating neural progenit...

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Literature Corpus work: 2f78821c-e3b7-5351-85c8-cbb258bf2d9b
DOI: 10.21203/rs.3.rs-7569882/v1

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