Article

Tumor immune microenvironment permissive to metastatic progression of ING4-deficient breast cancer

2024-05-14

Abstract excerpt

Deficiencies in the ING4 tumor suppressor are associated with advanced stage tumors and poor patient survival in cancer. ING4 was shown to inhibit NF-κB in several cancers. As NF-κB is a key mediator of immune response, the ING4/NF-κB axis is likely to manifest in tumor-immune modulation but has not been investigated. To characterize the tumor immune microenvironment associated with ING4-deficient tumors, three ap...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cf2d7583-af88-57eb-8ede-3d5b300e69bb
DOI: 10.1101/2024.05.09.593418

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tumor immune microenvironment permissive to metastatic progression of ING4-deficient breast cancerDOI 10.1101/2024.05.09.593418Read

p38 blockade reverses the immune suppressive tumor microenvironment in metastatic breast cancerSemantic proximity Read

p38 blockade reverses the immune suppressive tumor microenvironment in metastatic breast cancerSemantic proximity Read

Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.Semantic proximity Read

In vivo multidimensional CRISPR screens identify Lgals2 as an immunotherapy target in triple-negative breast cancerSemantic proximity Read

Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breastSemantic proximity Read

Single-cell and spatial transcriptome profiling identifies cellular heterogeneity and immunosuppressive tumor microenvironment in inflammatory breast cancerSemantic proximity Read

Phenotypic shifts of tumor associated macrophages and STAT3 mediated suppression of myeloid derived suppressor cells drive sensitization of HER2 <sup>+</sup> tumor immunitySemantic proximity Read

Hallmarks of Cancer: The Next GenerationSemantic proximity Read

Functional Genetic Screens Reveal Key Pathways Instructing the Molecular Phenotypes of Tumor-Associated MacrophagesSemantic proximity Read

Exploring ID4 as a Driver of Aggression and a Therapeutic Target in Triple-Negative Breast CancerSemantic proximity Read

Integrating genome-wide CRISPR immune screen with multi-omic clinical data reveals distinct classes of tumor intrinsic immune regulatorsSemantic proximity Read

An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment.Semantic proximity Read