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Single-cell and spatial transcriptome profiling identifies cellular heterogeneity and immunosuppressive tumor microenvironment in inflammatory breast cancer

1 Jun 2025

Abstract excerpt

INTRODUCTION: Inflammatory breast cancer (IBC) is a highly aggressive subtype of breast cancer associated with a poor prognosis. A better understanding of IBC's pathological and molecular basis is crucial for developing precision medicine strategies. OBJECTIVE: This study aimed to profile IBC at both the single-cell and spatial levels to examine immune cell populations, signaling pathways, and identify potential...

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PMID: 40460936
DOI: 10.1016/j.jare.2025.05.061

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