Article

Phenotypic shifts of tumor associated macrophages and STAT3 mediated suppression of myeloid derived suppressor cells drive sensitization of HER2 <sup>+</sup> tumor immunity

2021-01-30

Abstract excerpt

<h4>ABSTRACT</h4> Understanding how novel therapeutic combinations alter solid tumor microenvironments (TME) in immunosuppressive tumors such as breast cancer is essential to improve their responses to immune checkpoint inhibitors (ICIs). Entinostat, an oral histone deacetylase inhibitor (HDACi), has been shown to improve responses to ICIs in various tumor models with immunosuppressive TMEs, but the precise alter...

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Literature Corpus work: dac1f0c8-1837-5094-bf96-548b058e8a86
DOI: 10.1101/2021.01.29.428708

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