Article
An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment.
Nature communications - 3 Dec 2019
Tekpli Xavier, Lien Tonje, Røssevold Andreas Hagen, Nebdal Daniel, Borgen Elin, Ohnstad Hege Oma, Kyte Jon Amund, Vallon-Christersson Johan, Fongaard Marie, Due Eldri Undlien, Svartdal Lisa Gregusson, Sveli My Anh Tu, Garred Øystein, Frigessi Arnoldo, Sahlberg Kristine Kleivi, Sørlie Therese, Russnes Hege G, Naume Bjørn, Kristensen Vessela N
Abstract excerpt
How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three clusters of patients with gradual levels of immune infiltration. The intermediate immune infiltration cluster (Cluster B) is associated with a worse prognosis independently of known clinicopathological features. Furthermore, immune...
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