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In vivo multidimensional CRISPR screens identify Lgals2 as an immunotherapy target in triple-negative breast cancer

29 Jun 2022

Abstract excerpt

Immune checkpoint inhibitors exhibit limited response rates in patients with triple-negative breast cancer (TNBC), suggesting that additional immune escape mechanisms may exist. Here, we performed two-step customized in vivo CRISPR screens targeting disease-related immune genes using different mouse models with multidimensional immune-deficiency characteristics. In vivo screens characterized gene functions in the...

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PMID: 35767614
DOI: 10.1126/sciadv.abl8247

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