Back to search

Article

p38 blockade reverses the immune suppressive tumor microenvironment in metastatic breast cancer

2025-05-10

Abstract excerpt

<h4>ABSTRACT</h4> Metastatic breast cancer (MBC) is a life-threatening disease with limited therapeutic options. The immune suppressive tumor microenvironment (TME) limits the potency of the antitumor immune response and facilitates disease progression and metastasis. Our current study demonstrates that p38α is a druggable target in the TME that regulates the outcome of the immune-tumor interaction. The study rev...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6d229d93-3dcd-5d90-8ebe-dc32dc333791
DOI
10.1101/2025.05.08.652949
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
p38 blockade reverses the immune suppressive tumor microenvironment in metastatic breast cancerDOI 10.1101/2025.05.08.652949
p38 blockade reverses the immune suppressive tumor microenvironment in metastatic breast cancerSemantic proximity
Harnessing Inflammatory Monocytes to Overcome Resistance to Anti-PD-1 ImmunotherapySemantic proximity
Single-cell RNA sequencing reveals immunosuppressive pathways associated with metastatic breast cancerSemantic proximity
Tumor immune microenvironment permissive to metastatic progression of ING4-deficient breast cancerSemantic proximity
Tumor cell p38 inhibition to overcome immunotherapy resistanceSemantic proximity
Cracking the Codes behind Cancer Cells’ Immune EvasionSemantic proximity
TREM2+ macrophages regulate suppressive tumor microenvironment in TNBCSemantic proximity
Phenotypic shifts of tumor associated macrophages and STAT3 mediated suppression of myeloid derived suppressor cells drive sensitization of HER2 <sup>+</sup> tumor immunitySemantic proximity
Beyond the tumor microenvironment: Orchestrating systemic T‑cell response for next‑generation cancer immunotherapy (Review)Semantic proximity
A comprehensive single-cell map of T cell exhaustion-associated immune environments in human breast cancerSemantic proximity
Tumor Microenvironment: A Complex Landscape of Cancer Development and Drug ResistanceSemantic proximity
Identification of VISTA regulators in macrophages mediating cancer cell survivalSemantic proximity
Select a neighboring publication to make it the new centre.