Article

Exploring ID4 as a Driver of Aggression and a Therapeutic Target in Triple-Negative Breast Cancer

2025-02-08

Abstract excerpt

<h4>ABSTRACT</h4> Basal-like breast cancer (BLBC) is characterized by an aggressive clinical course, high genomic instability, and limited therapeutic options. The Inhibitor of Differentiation 4 (ID4) protein has been identified as a critical regulator of BLBC, where its overexpression correlates with poor prognosis. However, the mechanistic contributions of ID4 to BLBC tumorigenesis remain incompletely understoo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cffb0114-6ee5-5f8c-a3e6-f3f177d60e9f
DOI: 10.1101/2025.02.07.637072

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exploring ID4 as a Driver of Aggression and a Therapeutic Target in Triple-Negative Breast CancerDOI 10.1101/2025.02.07.637072Read

Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancerSemantic proximity Read

ID4 controls luminal lineage commitment in normal mammary epithelium and inhibits BRCA1 function in basal-like breast cancerSemantic proximity Read

A novel role for the HLH protein Inhibitor of Differentiation 4 (ID4) in the DNA damage response in basal-like breast cancerSemantic proximity Read

LSM4 drives the progression of triple-negative breast cancer through alternative splicingSemantic proximity Read

Single-Cell Transcriptome Analysis Revealed Heterogeneity and Identified Novel Therapeutic Targets for Breast Cancer SubtypesSemantic proximity Read

HDHD5 promotes triple-negative breast cancer growth and drives EMT-associated phenotypes via regulating S100A4.Semantic proximity Read

Multi-omics analysis identifies BICC1+ fibroblasts drive triple negative breast cancer aggressiveness and poor prognosisSemantic proximity Read

Super-enhancer-hijacking RBBP7 potentiates metastasis and stemness of breast cancer via recruiting NuRD complex subunit LSD1Semantic proximity Read

ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype.Semantic proximity Read

Identifying Novel Therapeutic Targets for Overcoming TNBC Chemo Resistance Through Comprehensive CRISPR-Cas9 Genome ScreeningSemantic proximity Read

BRCA1 and BRCA2 germline mutations driven signaling pathway alterations are sufficient to initiate breast tumorigenesis by the PIK3CA <sup>H1047R</sup> oncogeneSemantic proximity Read

Tumor immune microenvironment permissive to metastatic progression of ING4-deficient breast cancerSemantic proximity Read