Article

Changing the Waddington landscape to control mesendoderm competence

2019-12-06

Abstract excerpt

As pluripotent human embryonic stem cells progress towards one germ layer fate, they lose the ability to adopt alternative fates. It is unknown how the cells’ competence for these alternative fates changes along their developmental trajectory or if this competence can be modulated. Here, we show that a differentiating stem cell’s probability of adopting a mesendodermal fate when given the appropriate signal falls...

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Literature Corpus work: cf1915d2-2f7a-512f-9a20-72e9adf754d5
DOI: 10.1101/867010

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