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Article

The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution.

Science (New York, N.Y.) - 1 Jun 2018

Briggs James A, Weinreb Caleb, Wagner Daniel E, Megason Sean, Peshkin Leonid, Kirschner Marc W, Klein Allon M

Abstract excerpt

Time series of single-cell transcriptome measurements can reveal dynamic features of cell differentiation pathways. From measurements of whole frog embryos spanning zygotic genome activation through early organogenesis, we derived a detailed catalog of cell states in vertebrate development and a map of differentiation across all lineages over time. The inferred map recapitulates most if not all developmental...

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Identifiers

PMID: 29700227
DOI: 10.1126/science.aar5780
PMCID: PMC6038144

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