Article

Landscape of allele-specific transcription factor binding in the human genome

2020-10-08

Abstract excerpt

Sequence variants in gene regulatory regions alter gene expression and contribute to phenotypes of individual cells and the whole organism, including disease susceptibility and progression. Single-nucleotide variants in enhancers or promoters may affect gene transcription by altering transcription factor binding sites. Differential transcription factor binding in heterozygous genomic loci provides a natural source...

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Literature Corpus work: cefd1c4e-139a-5fed-9ae2-a9fcc6a9cb6b
DOI: 10.1101/2020.10.07.327643

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