Article

The architecture of allele-specific regulatory variant effects across five human genomes

2025-11-25

Abstract excerpt

<h4>ABSTRACT</h4> The overwhelming majority of genetic associations with complex traits and disease involve non-coding genetic variants. Those variants are substantially enriched in gene regulatory elements, indicating that allelic impacts on gene regulatory element activity is a major contributor to those associations. As a step towards fine mapping the mechanisms within those associations, several studies have...

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Literature Corpus work: a18a5bb2-b44c-5476-8603-76c5caf65795
DOI: 10.1101/2025.11.22.689315

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