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Article

Evaluating the impact of single nucleotide variants on transcription factor binding.

Nucleic acids research - 1 Dec 2016

Shi Wenqiang, Fornes Oriol, Mathelier Anthony, Wasserman Wyeth W

Abstract excerpt

Diseases and phenotypes caused by disrupted transcription factor (TF) binding are being identified, but progress is hampered by our limited capacity to predict such functional alterations. Improving predictions may be dependent on expanding the set of bona fide TF binding alterations. Allele-specific binding (ASB) events, where TFs preferentially bind to one of the two alleles at heterozygous sites, reveal the...

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Identifiers

PMID: 27492288
DOI: 10.1093/nar/gkw691
PMCID: PMC5137422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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