Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription.

doi:10.1126/science.1242463

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Article

Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription.

Science (New York, N.Y.) - 8 Nov 2013

Kilpinen Helena, Waszak Sebastian M, Gschwind Andreas R, Raghav Sunil K, Witwicki Robert M, Orioli Andrea, Migliavacca Eugenia, Wiederkehr Michaël, Gutierrez-Arcelus Maria, Panousis Nikolaos I, Yurovsky Alisa, Lappalainen Tuuli, Romano-Palumbo Luciana, Planchon Alexandra, Bielser Deborah, Bryois Julien, Padioleau Ismael, Udin Gilles, Thurnheer Sarah, Hacker David, Core Leighton J, Lis John T, Hernandez Nouria, Reymond Alexandre, Deplancke Bart, Dermitzakis Emmanouil T

Abstract excerpt

DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. To understand the interplay between chromatin and genetic control of gene regulation, we quantified allelic variability in transcription factor binding, histone modifications, and gene expression within humans. We found abundant allelic...

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PMID: 24136355
DOI: 10.1126/science.1242463
PMCID: PMC5502466

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