Article
Allele-specific transcription factor binding across human brain regions offers mechanistic insight into eQTLs.
Genome research - 20 Sept 2024
Anderson Ashlyn G, Moyers Belle A, Loupe Jacob M, Rodriguez-Nunez Ivan, Felker Stephanie A, Lawlor James M J, Bunney William E, Bunney Blynn G, Cartagena Preston M, Sequeira Adolfo, Watson Stanley J, Akil Huda, Mendenhall Eric M, Cooper Gregory M, Myers Richard M
Abstract excerpt
Transcription factors (TFs) regulate gene expression by facilitating or disrupting the formation of transcription initiation machinery at particular genomic loci. Because TF occupancy is driven in part by recognition of DNA sequence, genetic variation can influence TF-DNA associations and gene regulation. To identify variants that impact TF binding in human brain tissues, we assessed allele-specific binding (ASB)...
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