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Article

Large-scale identification of sequence variants influencing human transcription factor occupancy in vivo.

Nature genetics - 1 Dec 2015

Maurano Matthew T, Haugen Eric, Sandstrom Richard, Vierstra Jeff, Shafer Anthony, Kaul Rajinder, Stamatoyannopoulos John A

Abstract excerpt

The function of human regulatory regions depends exquisitely on their local genomic environment and on cellular context, complicating experimental analysis of common disease- and trait-associated variants that localize within regulatory DNA. We use allelically resolved genomic DNase I footprinting data encompassing 166 individuals and 114 cell types to identify >60,000 common variants that directly influence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26502339
DOI: 10.1038/ng.3432
PMCID: PMC4666772

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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